If other psychotropic medications are withdrawn following stabilization, the dose of lamictal should be adjusted.
Information about Lamictal.
While atazanavir/ritonavir does reduce the lamotrigine plasma concentrationno adjustments to the recommended dose-escalation guidelines for LAMICTAL should be necessary solely based on the use of atazanavir/ritonavirDose escalation should follow the recommended guidelines for initiating adjunctive therapy with LAMICTAL based on concomitant AED or other concomitant medicationssee Tables 12and 5In patients already taking maintenance doses of LAMICTAL and not taking glucuronidation inducersthe dose of LAMICTAL may need to be increased if atazanavir/ritonavir is addedor decreased if atazanavir/ritonavir is discontinuedsee CLINICAL PHARMACOLOGY
Lamotrigine has been reported to interfere with the assay used in some rapid urine drug screenswhich can result in false-positive readingsparticularly for phencyclidinePCPA more specific analytical method should be used to confirm a positive result.
Some estrogen-containing oral contraceptives have been shown to decrease serum concentrations of lamotriginesee CLINICAL PHARMACOLOGYDosage adjustments will be necessary in most patients who start or stop estrogen-containing oral contraceptives while taking LAMICTALsee DOSAGE AND ADMINISTRATIONDuring the week of inactive hormone preparationpill-free weekof oral contraceptive therapyplasma lamotrigine levels are expected to riseas much as doubling at the end of the weekAdverse reactions consistent with elevated levels of lamotriginesuch as dizzinessataxiaand diplopiacould occur.
Weight gain Impaired memory Poor concentration Confusion Mental slowness Hand tremor Sedation or lethargy Impaired coordination Nauseavomitingor diarrhea Hair loss Acne Excessive thirst and dry mouth Excessive urination Decreased thyroid functionwhich can be treated with thyroid hormone)
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