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The volunteers blood naltrexone concentrations began to rise within minutes of the patch application, stabilized at an average of about 2.

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In the clinical studiestreatment with REVIA supported abstinenceprevented relapse and decreased alcohol consumptionIn the uncontrolled studythe patterns of abstinence and relapse were similar to those observed in the controlled studiesREVIA was not uniformly helpful to all patientsand the expected effect of the drug is a modest improvement in the outcome of conventional treatment.

There are no systematically collected data that specifically address the switch from buprenorphine or methadone to REVIAhoweverreview of postmarketing case reports have indicated that some patients may experience severe manifestations of precipitated withdrawal when being switched from opioid agonist therapy to opioid antagonist therapysee WARNINGSPatients transitioning from buprenorphine or methadone may be vulnerable to precipitation of withdrawal symptoms for as long as 2 weeksHealthcare providers should be prepared to manage withdrawal symptomatically with non-opioid medications.

Irrespective of the drug chosen to reverse REVIA blockadethe patient should be monitored closely by appropriately trained personnel in a setting equipped and staffed for cardiopulmonary resuscitation.

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in addition to these implant risks, naltrexone therapy can cause withdrawal symptoms if a patient isn t fully detoxed when treatment begins.

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